Extravasation injury (the discharge or escape of blood or some other fluid normally found in a vessel or tube into the surrounding tissue) occurs in approximately 1% of patients undergoing chemotherapy. It is associated with significant morbidity. Several studies have shown topical application of DMSO to be effective in treating this problem.
Stephen B. Strum, M.D., a medical oncologist, reports that in his experience "regular DMSO application can completely reverse extravasation injury even when treatment is delayed." He reports the only toxicity he has seen in twenty years of using DMSO has been a stinging or burning sensation during initial application.